The Crystal Structure of Terramycin Hydrochloride.
نویسندگان
چکیده
The problem of determining the arrangements of atoms in crystals directly from X-ray diffraction data has engaged the attention of crystallographers for some time, and a number of approaches to this general problem have been presented. We have been especially interested in the approach which makes use of imageseeking functions in solving the Patterson synthesis,' which, in turn, is based entirely on observable X-ray diffraction data. Many simple and moderately complex structures have been solved directly from X-ray diffraction data by this route. We wished to test the power of the method on a somewhat more complex structure, and we regarded the antibiotics as well suited to this purpose. In order to focus attention on the problem and not on the details of gathering the X-ray diffraction data, we canvassed our colleagues for a full set of threedimensional diffraction data for a structure as yet unsolved. Professor Ray Pepinsky kindly made available to us such data for terramycin hydrochloride which had been gathered in his laboratory by Dr. J. H. Robertson. Professor Pepinsky further supplied us with sections of the three-dimensional Patterson function for these data, as computed by his X-RAC. Space group and unit cell: Crystals of terramycin hydrochloride are orthorhombic, space group P212121, and have the following cell dimensions:
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ورودعنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 46 10 شماره
صفحات -
تاریخ انتشار 1960