The Crystal Structure of Terramycin Hydrochloride.

نویسندگان

  • Y Takeuchi
  • M J Buerger
چکیده

The problem of determining the arrangements of atoms in crystals directly from X-ray diffraction data has engaged the attention of crystallographers for some time, and a number of approaches to this general problem have been presented. We have been especially interested in the approach which makes use of imageseeking functions in solving the Patterson synthesis,' which, in turn, is based entirely on observable X-ray diffraction data. Many simple and moderately complex structures have been solved directly from X-ray diffraction data by this route. We wished to test the power of the method on a somewhat more complex structure, and we regarded the antibiotics as well suited to this purpose. In order to focus attention on the problem and not on the details of gathering the X-ray diffraction data, we canvassed our colleagues for a full set of threedimensional diffraction data for a structure as yet unsolved. Professor Ray Pepinsky kindly made available to us such data for terramycin hydrochloride which had been gathered in his laboratory by Dr. J. H. Robertson. Professor Pepinsky further supplied us with sections of the three-dimensional Patterson function for these data, as computed by his X-RAC. Space group and unit cell: Crystals of terramycin hydrochloride are orthorhombic, space group P212121, and have the following cell dimensions:

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Clinical Observations on Terramycin *†

In a recent report, Finlay, Hobby, and their collaborators1 have described a new crystalline antibiotic, terramycin, isolated from broth cultures of a new actinomycete, Streptomnyces rimosus. In vitro studies8 of terramycin and its salts have shown that this antibiotic in low concentrations is a highly effective bacteriostatic agent against a wide variety of gram-positive and gram-negative bact...

متن کامل

Treatment of non-gonococcal urethritis with intramuscular tetracycline (terramycin).

The place of oral oxytetracycline hydrochloride (Terramycin) therapy in the treatment of nongonococcal urethritis (N.G.U.) is well established (Harkness, 1953; Willcox, 1957; Morton and Read, 1957). Success rates of about 85 per cent. are above those obtained by other antibiotics, sulphomanides, or a combination of these. The trial reported below was undertaken at a time when a degree of penici...

متن کامل

X-Ray Crystal Structure of [N, N'-bis(4-Methoxysalicylidene) -2, 3-Dimethylaminopropane] Copper(II) Ethanol Solvate

The crystal structure of the title Schiff base complex is obtained by single-crystal X-ray diffraction data.The solid state structure determination reveals that the coordination geometry around the copper(II) center istetrahedrally distorted square-planar. The crystal packing shows one dimensional infinite chains which arisesfrom the intermolecular interaction and stabilize the crystal packing.

متن کامل

Redetermination of Crystal Structure of N,N'-bis (2-Hydroxybenzylidene)-2,2-Dimethyl-1,3-Propanediamine

The structure of N,N'-bis(2-hydroxybenzylidene)-2,2-dimethyl-1,3-propanediamine, C19H22N2O2, has been studied at low temperature (120K) by means of single-crystal X-ray diffraction. Solving the structure shows an orthorhombic unit cell, with P212121 space group, Z = 4, a = 6.1046 (4) Å, b = 15.8349 (11)</e...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Proceedings of the National Academy of Sciences of the United States of America

دوره 46 10  شماره 

صفحات  -

تاریخ انتشار 1960